{"id":84119,"date":"2024-09-03T14:30:41","date_gmt":"2024-09-03T05:30:41","guid":{"rendered":"https:\/\/japan-indepth.jp\/?p=84119"},"modified":"2024-10-18T10:17:31","modified_gmt":"2024-10-18T01:17:31","slug":"%e3%83%9c%e3%82%b9%e3%83%88%e3%83%b3%e3%83%bb%e3%82%a6%e3%82%a7%e3%83%ab%e3%83%8d%e3%82%b9%e9%80%9a%e4%bf%a1%e3%80%80%e3%81%9d%e3%81%ae12-glp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac","status":"publish","type":"post","link":"https:\/\/japan-indepth.jp\/?p=84119","title":{"rendered":"\u30dc\u30b9\u30c8\u30f3\u30fb\u30a6\u30a7\u30eb\u30cd\u30b9\u901a\u4fe1\u3000\u305d\u306e12 GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3001\u9577\u671f\u7684\u306a\u6210\u529f\u306e\u9375"},"content":{"rendered":"<div class=\"e6f52dc566d20a520ffae7bd1dec9ffb\" data-index=\"3\" style=\"float: none; margin:5px 0 5px 0; text-align:center;\">\n<!-- A_728*90 -->\r\n<div class=\"ad-set\">\r\n<style type=\"text\/css\">\r\n.adslot_2 { width: 100%; height: 94px; text-align:center 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href=\"https:\/\/japan-indepth.jp\/?tag=%E5%A4%A7%E8%A5%BF%E7%9D%A6%E5%AD%90\" data-rich-text-format-boundary=\"true\">\u5927\u897f\u7766\u5b50<\/a>\uff08\u7c73\u56fd\u30dc\u30b9\u30c8\u30f3\u5728\u4f4f\u5185\u79d1\u533b\u5e2b\uff09<\/p>\n<p><strong>\u3010\u307e\u3068\u3081\u3011<\/strong><\/p>\n<p><strong>\u30fb\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u793e\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u300c\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u304c\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u6700\u592794%\u4f4e\u4e0b\u300d\u3068\u3044\u3046\u9a5a\u7570\u7684\u306a\u30c7\u30fc\u30bf\u3092\u516c\u8868\u3002<\/strong><\/p>\n<p><strong>\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3084\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u306a\u3069\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u52b9\u679c\u304c\u9ad8\u307e\u308b\u3002<\/strong><\/p>\n<p><strong>\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u9ad8\u9f62\u8005\u306e\u751f\u6d3b\u306e\u8cea\u3082\u5411\u4e0a\u3055\u305b\u308b\u304c\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3084\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/strong><\/p>\n<p>\u3000\u5148\u65e530\u4ee3\u524d\u534a\u7537\u6027B\u3055\u3093\u306b\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3064\u3044\u3066\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u3000B\u3055\u3093\u306f\u3001\u3082\u3068\u3082\u3068\u4f53\u80b2\u4f1a\u7cfb\u7537\u5b50\u3002\u4ee5\u524d\u306f\u91ce\u7403\u3001\u30a2\u30af\u30b7\u30e7\u30f3\u30b9\u30dd\u30fc\u30c4\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u904b\u52d5\u3092\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u306f\u30b4\u30eb\u30d5\u3068\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3092\u5c11\u3005\u3002\u8cac\u4efb\u611f\u304c\u5f37\u304f\u3001\u7269\u4e8b\u3084\u308b\u3068\u6c7a\u3081\u305f\u3089\u6700\u5f8c\u307e\u3067\u3084\u308a\u9042\u3052\u308b\u6027\u8cea\u3067\u3059\u3002<\/p>\n<p>\u3000\u305f\u3060\u3057\u793e\u4f1a\u4eba\u306a\u308a20\u4ee3\u524d\u534a\u9803\u304b\u3089\u751f\u6d3b\u304c\u4e00\u5909\u3002B\u3055\u3093\u306f\u300c\u6bce\u65e55\u6642\u306b\u8d77\u5e8a\u3057\u7d42\u96fb\u3092\u5229\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u597d\u304d\u306a\u904b\u52d5\u304c\u3067\u304d\u305a\u3001\u98df\u3079\u904e\u304e\u3001\u98f2\u9152\u91cf\u304c\u5897\u3048\u3066\u4f53\u91cd\u304c\u5897\u3048\u307e\u3057\u305f\u3002\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u304c\u60aa\u5316\u3057\u3066\u3001\u65e5\u4e2d\u7720\u304f\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u304c\u305f\u307e\u308a\u307e\u3057\u305f\u300d\u3068\u3044\u3044\u307e\u3059\u3002<\/p>\n<p>\u3000\u305d\u3093\u306a\u72b6\u6cc1\u3067\u3001\u4e3b\u6cbb\u533b\u304b\u3089\u30011\u30f6\u6708\u524d\u306bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u51e6\u65b9\u3092\u53d7\u3051\u305f\u305d\u3046\u3067\u3059\u3002\u3059\u308b\u3068\u300c1\u30f6\u6708\u5f8c\u306b\u306f\u904e\u98df\u304c\u6e1b\u308a\u3001\u4f53\u91cd\u304c\uff13\u301c4\u30ad\u30ed\u6e1b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u98f2\u9152\u304c1\u65e5\u5e73\u5747\u30d3\u30fc\u30eb3\u676f\u304b\u3089\u30d3\u30fc\u30eb1\u676f\uff08\u3042\u308b\u3044\u306f\u3001\u30ef\u30a4\u30f31.5\u672c\u304c\u30ef\u30a4\u30f30.5\u672c\u3001\u30a6\u30a3\u30b9\u30ad\u30fc6\u676f\u304c\u30a6\u30a3\u30b9\u30ad\u30fc2\u676f\uff09\u306b\u6e1b\u308a\u307e\u3057\u305f\u3002\u6700\u8fd1\u306f\u7761\u7720\u306e\u8cea\u304c\u9ad8\u307e\u308a\u3001\u4f53\u8abf\u304c\u6539\u5584\u3057\u3066\u3044\u307e\u3059\u300d\u3068\u306e\u3053\u3068\u3002\u4ed5\u4e8b\u306e\u8abf\u5b50\u3082\u826f\u3055\u305d\u3046\u3067\u3059\u3002<\/p>\n<p>\u3000\u305d\u3093\u306aB\u3055\u3093\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u304c\u3088\u304f\u52b9\u3044\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u304c\u3001\u9577\u671f\u7684\u306b\u306f\u3069\u3046\u306a\u308b\u306e\u3067\u3057\u3087\u3046\uff1f<\/p>\n<p>\u25cf\u3000\u7d50\u5c40\u306e\u3068\u3053\u308d\u3001\u4f53\u91cd\u7ba1\u7406\u306f\u9577\u671f\u7684\u306a\u53d6\u308a\u7d44\u307f<\/p>\n<p>\u3000\u5148\u65e5\u3001<strong>\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u793e\u306f\u30013 \u5e74\u9593\u306b\u308f\u305f\u308b SURMOUNT 1 \u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u300c\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u304c\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u6700\u592794%\u4f4e\u4e0b\u300d\u3068\u3044\u3046\u9a5a\u7570\u7684\u306a\u30c7\u30fc\u30bf\u3092\u516c\u8868\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u300c\u30c1\u30eb\u30bc\u30d1\u30bf\u30a4\u30c9\u304c 3 \u5e74\u9593\u306b\u308f\u305f\u308a\u6e1b\u91cf\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u52b9\u679c\u7684\u300d\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff081\uff09\u3002<\/strong><\/p>\n<p style=\"text-align: center;\">\u3000\uff0a\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u793e\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff1a\uff12\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3067\u6e1b\u91cf\u52b9\u679c\u306e\u3042\u308b\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08\u5546\u54c1\u540d\u30de\u30f3\u30b8\u30e3\u30ed\uff09\u3001\u6e1b\u91cf\u306e\u305f\u3081\u306e\u9ad8\u7528\u91cf\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08\u5546\u54c1\u540d\u30bc\u30c3\u30d7\u30d0\u30a6\u30f3\u30c9\uff09\u3002\u3061\u306a\u307f\u306b\u30ce\u30dc \u30ce\u30eb\u30c7\u30a3\u30b9\u30af\u793e\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u80a5\u6e80\u6cbb\u7642\u85ac\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08\u5546\u54c1\u540d\u30a6\u30b4\u30fc\u30d3\uff09\u3001\uff12\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3067\u6e1b\u91cf\u52b9\u679c\u306e\u3042\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08\u5546\u54c1\u540d\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\uff1a\u30a6\u30b4\u30fc\u30d3\u3088\u308a\u3082\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306e\u7528\u91cf\u304c\u5c11\u306a\u3044\uff09\u3002<\/p>\n<p>\u3000\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u524d\u7cd6\u5c3f\u75c5\u3068\u80a5\u6e80\u3001\u305d\u306e\u4ed6\u306e\u4f53\u91cd\u7ba1\u7406\u306e\u554f\u984c\u3092\u62b1\u3048\u308b\u6210\u4eba 1,032 \u540d\u304c\u8abf\u67fb\uff08\u591a\u65bd\u8a2d\u5171\u540c\u3001\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\uff09\u306e\u5bfe\u8c61\u3067\u3059\u3002176 \u9031\u9593\u306e\u6cbb\u7642\u671f\u9593\u3068\u3001\u305d\u308c\u306b\u7d9a\u304f 17 \u9031\u9593\u306e\u6cbb\u7642\u4f11\u6b62\u671f\u9593 \uff08\u5408\u8a08 193 \u9031\u9593\uff09 \u3067\u8a55\u4fa1\u3057\u307e\u3059\u3002\u53c2\u52a0\u8005\u306f\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u98df\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u7fd2\u6163\u3092\u6307\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3061\u306a\u307f\u306b72 \u9031\u6642\u70b9\u3067\u306e\u89e3\u6790\u7d50\u679c\u306f\u30012022 \u5e74\u306e \u533b\u5b66\u8a8cNew England Journal of Medicine \u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3000\u30c1\u30eb\u30bc\u30d1\u30bf\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u53c2\u52a0\u8005\u306f\u3001\u6bce\u9031 5 mg\u300110 mg\u3001\u307e\u305f\u306f 15 mg \u306e\u6ce8\u5c04\u3001\u305d\u306e\u4ed6\u306e\u53c2\u52a0\u8005\u306f\u30d7\u30e9\u30bb\u30dc\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<strong>\u7d50\u679c\u3001176 \u9031\u9593\u306b\u308f\u305f\u308a\u30c1\u30eb\u30bc\u30d1\u30bf\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u53c2\u52a0\u8005\u306f\u30012 \u578b\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u304c94% \u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/strong><\/p>\n<p>\u3000\u307e\u305f\u300115 mg \u6295\u4e0e\u3092\u53d7\u3051\u305f\u53c2\u52a0\u8005\u306f\u4f53\u91cd\u304c\u5e73\u5747\u7d04 23% \u6e1b\u5c11\u300110mg \u6295\u4e0e\u3092\u53d7\u3051\u305f\u53c2\u52a0\u8005\u306f\u5e73\u5747\u7d04 20% \u306e\u4f53\u91cd\u6e1b\u5c11\u30015mg \u6295\u4e0e\u3092\u53d7\u3051\u305f\u53c2\u52a0\u8005\u306f\u5e73\u5747\u7d04 15% \u306e\u4f53\u91cd\u6e1b\u5c11\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3000\u305f\u3060\u3057176\u9031\u9593\u5f8c\u306b\u30c1\u30eb\u30bc\u30d1\u30bf\u30a4\u30c9\u306e\u6295\u4e0e\u3092\u4e2d\u6b62\u3057\u305f\u53c2\u52a0\u8005\u306f\u3001\u4f53\u91cd\u304c\u623b\u308a\u59cb\u3081\u3066\u300117\u9031\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b2\u578b\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u306e\u5146\u5019\u3082\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3000\u5c02\u9580\u5bb6\u3089\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u306b\u306f\u540c\u610f\u3057\u3066\u3044\u307e\u3059\u304c\u3001<strong>\u300c\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306e\u6cbb\u9a13\u306b\u304a\u3051\u308b\u6cbb\u7642\u5f8c\u306e\u30c7\u30fc\u30bf\u306f\u3001\u6e1b\u91cf\u306f\u9577\u671f\u7684\u306a\u53d6\u308a\u7d44\u307f\u3067\u3042\u308b\u3068\u3044\u3046\u8003\u3048\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u300d\u3001\u305d\u3057\u3066\u300c\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u3068\u5b9a\u671f\u7684\u306a\u904b\u52d5\u306b\u3088\u308b\u9577\u671f\u7684\u306a\u6e1b\u91cf\u3078\u306e\u53d6\u308a\u7d44\u307f\u3092\u63a8\u5968\u300d\uff082\uff09\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n<p>\u3000\u3055\u3066B\u3055\u3093\u306f\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u5f8c\u3001\u300c\u4eca\u65e5\u304b\u3089\u30e9\u30f3\u30cb\u30f3\u30b0\u3092\u30b9\u30bf\u30fc\u30c8\u3057\u307e\u3059\u3002\u30e9\u30f3\u30cb\u30f3\u30b0\u00d7GLP-1\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3057\u307e\u3059\u300d\u3068\u8a00\u3044\u5207\u308a\u307e\u3057\u305f\u3002\u904b\u52d5\u7fd2\u6163\u3092\u5fa9\u6d3b\u3055\u305b\u308b\u3053\u3068\u3092\u6c7a\u5fc3\u3057\u305f\u3088\u3046\u3067\u3059\u3002\u307e\u305a\u306f\u7121\u7406\u306a\u304f\u30e9\u30f3\u30cb\u30f3\u30b0\u3092\u59cb\u3081\u3066\u3001\u9577\u671f\u7684\u306a\u6e1b\u91cf\u3068\u76ee\u6a19\u4f53\u91cd\u306b\u9054\u3057\u305f\u5f8c\u306e\u4f53\u91cd\u7dad\u6301\u3092\u76ee\u6a19\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u25cf\u3000\u904b\u52d5\u3084\u98df\u4e8b\u3067\u3001\u81ea\u7136\u306bGLP-1\u306e\u5206\u6ccc\u3092\u6539\u5584<\/p>\n<p>\u3000\u307e\u3060\u307e\u3060\u3001\u8eab\u4f53\u6d3b\u52d5\u3068GLP-1\u306e\u95a2\u4fc2\u306f\u308f\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3082\u306e\u306e\u3001<strong>\u77ed\u671f\u304a\u3088\u3073\u9577\u671f\u306e\u904b\u52d5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u3001GLP-1\u306e\u5206\u6ccc\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059<\/strong>\uff083\uff09\uff084\uff09\uff085\uff09\u3002<\/p>\n<p>\u3000\u307e\u305f\u3001\u5168\u7c92\u7a40\u7269\u3084\u91ce\u83dc\u306e\u3088\u3046\u306a\u98df\u7269\u7e4a\u7dad\u306e\u591a\u3044\u98df\u54c1\u306f\u3001\u305f\u3093\u3071\u304f\u8cea\u3084\u5065\u5eb7\u7684\u306a\u8102\u80aa\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3068\u3068\u3082\u306b\u3001GLP-1\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u30012016 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65%\u300163%\u300159% \u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5375\u5de3\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f 48% \u4f4e\u4e0b\u3057\u3001\u809d\u7d30\u80de\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f 53% 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6\u306b\u76f8\u8ac7\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\uff081\uff09https:\/\/investor.lilly.com\/news-releases\/news-release-details\/tirzepatide-reduced-risk-developing-type-2-diabetes-94-adults<\/p>\n<p>\uff082\uff09https:\/\/www.healthline.com\/health-news\/mounjaro-zepbound-lowers-diabetes-risk<\/p>\n<p>\uff083\uff09https:\/\/academic.oup.com\/jes\/article\/6\/9\/bvac111\/6650333<\/p>\n<p>\uff084\uff09https:\/\/journals.physiology.org\/doi\/full\/10.1152\/japplphysiol.00680.2018<\/p>\n<p>\uff085\uff09https:\/\/journals.physiology.org\/doi\/full\/10.1152\/japplphysiol.00239.2018<\/p>\n<p>\uff086\uff09https:\/\/nutritionandmetabolism.biomedcentral.com\/articles\/10.1186\/s12986-016-0153-3<\/p>\n<p>\uff087\uff09https:\/\/www.foxnews.com\/health\/ozempic-push-seniors-doctors-say-more-people-age-65-should<\/p>\n<p>\uff088\uff09https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2820833<\/p>\n<p>\uff089\uff09https:\/\/www.kff.org\/health-costs\/poll-finding\/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs\/<\/p>\n<p>\uff0810\uff09https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2032183<\/p>\n<p><b><\/b><\/p>\n<p>\u00a0<\/p>\n\n<div 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